In a small pilot feasibility study of Modafinil Australia in cocaine-dependent patients with advanced non-small-cell lung cancer (NSCLC), the drug was found to reduce fatigue and enhance the quality of life. This was followed by a larger randomized clinical trial, which was designed to evaluate its efficacy in this patient population and to test the hypothesis that it also has beneficial effects on daytime sleepiness and depression. In this study, adults with advanced NSCLC and performance status 0-2 were randomly assigned to daily modafinil or placebo. The dose was titrated over 28 days to reach a target of two pills per day, which was determined by a preliminary feasibility study.
Patient assessments were taken at baseline, 14 days, and 28 days of treatment. Participants were excluded from the study if they were dependent on drugs other than cocaine or nicotine, had serious active medical illness (including uncontrolled hypertension or significant cardiac, renal, or hepatic disease), had psychiatric illness (history of bipolar disorder, current major depression ), were pregnant, were taking psychotropic medication or medications that could interact with Modafinil, and did not have adequate alternative birth control.
Alternative medicine is Modalert 100 mg
Patient assessments were taken at baseline, 14 days, and 28 days of treatment. Participants were excluded from the study if they were dependent on drugs other than cocaine or nicotine, had serious active medical illness (including uncontrolled hypertension or significant cardiac, renal, or hepatic disease), had psychiatric illness (history of bipolar disorder, current major depression ), were pregnant, were taking psychotropic medication or medications that could interact with Modafinil, and did not have adequate alternative birth control.
Alternative medicine is Modalert 100 mg
